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100,101 This is coupled with the upregulation of the cell cycle regulators P16, P21, and P53, leading to cell cycle arrest and diminished proliferative capacity

Growth hormone, IGF-I, and insulin are known to influence these pathways, which have provided the basis for their use as PEDs (see figure 1)

Changes in cardiac function during the development of uremic cardiomyopathy and the effect of salvianolic acid B administration in a rat model

doi: 10.1016/j.celrep.2021.109720 72 JonesK

Geldenhuys W, Mbimba T, Bui T, Harrison K, Sutariya V
