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b: Atypia and mitotic figures were not identified in the superficial part of the dermis, but maturation was invariably present (Hematoxylin-eosin stain, 400X)

Immunization with alpha-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model

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doi: 10.3389/fonc.2020.01056 36 BurdCELiuWHuynhMVWaqasMAGillahanJEClarkKSet al

The reason is that only one nucleotide substitution is needed relative to the subtype 1a sequence to generate this variant, whereas two substitutions are needed relative to the 1b sequence (codon usage bias)