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All they mean is that there is fragmentation injury to RBC and, even though affected RBC will have decreased lifespan, it does not mean the animal has a fragmentation hemolytic anemia

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It appears clear that the therapeutic potential of HO-1 in mediating the resolution of inflammation and tissue homeostasis may reside in specific phases of the inflammatory cascade and the regulation of hematopoietic output, thus calling for further study to fully characterize its therapeutic potential in different pathological contexts

Quantitative real-time PCR (qRT-PCR) was performed using 2 sybr Green qPCR MasterMix (Sevenbio, Beijing) and the ABI StepOnePlus real-time PCR system (Applied Biosystems, United States), with -actin as the internal reference

At the same time, drugs also have a certain degree of side effects, such as the development of drug resistance, as well as adverse reactions to gastrointestinal symptoms, neurological and psychiatric symptoms, and other systemic symptoms