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Pharmacokinetic modeling and clinical experience support this approach, though no head-to-head randomized trial has compared 1.5 mg twice weekly versus 2.5 mg once weekly

Different species and even strains metabolize compounds differently, requiring species-specific adjustments to the 5-Amino-1MQ dosage

287 Consequently, iron dyshomeostasis and deficient activity of ironsulfur enzymes are hallmarks of FRDA and may be major etiological components, perhaps together with increased ROS levels caused by mitochondrial iron accumulation

Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains

Kariya C, Chu HW, Huang J, Leitner H, Martin RJ, Day BJ: Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stress