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[DOI] [PubMed] [Google Scholar] 63.Tahir M., Sultana S

Moreover, a comparative oncogenomic analysis identified that SHMT2, another mitochondrial gene involved in 1C metabolism, is amplified and is very important for tumor development [103]

First, while Jnk2 was globally deleted in all cell types, Jnk1 was specifically ablated in hepatocytes but present in non-parenchymal cells, implying an opposing role of Jnk1 in different subsets of liver cells as well as in infiltrated inflammatory cells

Given that the antioxidant enzymes SOD1 and GPX4 are highly expressed in most tumors, copper depletion-induced SOD1 inhibition and copper overload-induced GPX4 degradation may have great potential as a viable anticancer strategy

(E) RT-qPCR was used to detect the relative expression of cyclin D1, Axin 2, and c-Myc mRNA in the Hp, Hp-KS-1, Hp+-KG negative control, and corresponding RPL15 knockdown groups