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For genes that promote DNA damage repair (e.g., ATM/ERCC1 ), DNA methylation can increase the sensitivity of tumors to radiation, while demethylation leads to radiotherapy resistance in tumor cells 452,453 (Fig

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In metastatic bone tumors, fungal-derived -glucans and mannans can interact with osteoblasts and osteoclasts to modulate bone resorption and deposition

Diabetes 2004;53:2910-2920

Most users start noticing gradual changes somewhere between four to twelve weeks of consistent use
