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Berberine, another representative TCM constituent for metabolic disorders, also exerts its effects through bidirectional interaction with the gut microbiota

Funding Statement The present study is supported by the National Natural Science Foundation of China (No

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In the 536 bp site of the proximal promoter of GGT, a binding site exists between p50, TNF- and Sp1, regulated by the activation of the NF-B signaling pathway, thereby promoting expression of GGT and inducing inflammatory response (Fig

Rho-associated, coiled-coil-containing protein kinase (ROCK), a serine/threonine kinase involved in fatty acid metabolism, has been observed to be significantly activated in DKD