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Expert Clinical Visual Grading: An independent trained evaluator assessed hyperpigmentation severity and skin tone evenness under standardised conditions at both timepoints, using a validated PCR clinical grading scale

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Methods Plasma levels of PGA, kynurenine, and tryptophan were quantified by liquid chromatography-mass spectrometry in cohorts comprising healthy TTR wild-type controls, asymptomatic carriers of the TTR-V30M mutation, and symptomatic patients with TTR-V30M amyloidosis

While aldose reductase contributes to MG metabolism, the glyoxalase system is expected to be the primary route in most human tissues under normal conditions, except for the renal medulla, which has unusually high levels of aldose reductase [83]

53,7981 In vitro studies have revealed that the GSTP1-null cell lines show a different degree of resistance in response to TLK286 compared with GSTP1 +/+ cells