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These enzyme localizations mean that neuronal tissue may be particularly vulnerable to H 2 O 2 , resulting in the formation of ROS that are known to be involved in a number of acute and chronic pathological conditions in the brain and neural tissue

Regarding its multi-functionality as a nutrient, protein folding, and major component for redox balance due to its involvement in glutathione synthesis, disruption of cysteine homeostasis appears to be promising strategy for induction of cancer cell death

51,52 The development of a prognostic model for survivability of APAP hepatotoxicity, with or without liver transplant, was an important achievement to delineate need for emergency transplantation

The qRT-PCR assays were carried out on three biological replicates

Recent advancements have introduced alternative extraction methods, such as microwave-assisted, ultrasonic, and enzyme-assisted techniques, which have addressed some of these limitations to varying degrees