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Notably, studies have demonstrated that in diabetic conditions, depletion of the mitochondrial thioredoxin-2 (Trx2)/GSH system in db/db mice disrupts redox homeostasis, resulting in lipid peroxidation of the mitochondrial membrane and impaired activity of respiratory chain complexes

[DOI] [PubMed] [Google Scholar] 193.Waymire K.G., Mahuren J.D., Jaje J.M., Guilarte T.R., Coburn S.P., MacGregor G.R

Heat stress responses in spermatozoa: mechanisms and consequences for cattle fertility

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Besides, most antidepressants share common challenges, including a marked therapeutic delay of several weeks, limited bioavailability, poor bloodbrain barrier permeability, and instability in the gastrointestinal tract (Ferrari and Villa, 2017