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The differentiation protocol utilized was developed and optimized from the published literatures 18,19,20,21 , specifically chosen for its capacity to generate iHLOs with high CYP enzyme activity, particularly CYP3A4, which is crucial for drug metabolism and toxicology evaluations
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Studies have shown that individuals who are dehydrated may exhibit higher BAC levels than if they were properly hydrated, given the same amount of alcohol consumption
Kotowska, and S
View on PubMed Seiwerth S, Brcic L, Sila D, et al
