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Differentiated myotubes were treated for 2 h with 100 ng/ml TNF- (PeproTech, Rocky Hill, USA) to establish a muscle atrophy cell model

It is an essential cofactor of the electron transport chain and helps maintain mitochondrial membrane potential [95]

doi: 10.1016/j.ymgme.2012.03.021

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Animal models could be of help in better understanding the molecular basis of MVP, possibly providing sufficient information to tackle specific mechanisms aimed at slowing down MVP progression, therefore developing non-surgical therapies impacting on the natural history of this condition