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The direct assessment of MDA and 4-HNE is not very sensitive, since the major portion of these reactive aldehydes is attached to proteins or other biomolecules and therefore before analysis, should be released, otherwise, they remain undetected (Esterbauer et al
In SCD, abnormal haemoglobin causes red blood cells to stiffen into a characteristic sickle shape under low-oxygen conditions
10.1021/acsbiomaterials.2c00023 72 MaX.FengY.WangT.LeiW.LiX.ZhouD.et al (2017)
Jing et al
doi: 10.1016/j.mce.2017.01.038 148
