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2016;11(1) doi: 10.1371/journal.pone.0147858.e0147858 [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Rossignol D

After the short-term combined treatment, the patient continued to take traditional treatment (orally isotretinoin) for 4 months, and the skin lesions did not recur after stopping the drug (Figures 1g, h)

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There is the classically activated M1 macrophage state associated with pro-inflammatory effects, anti-tumor signals, stimulation of cytotoxic T-cells, secretion of cytokines like interleukin (IL)-12, tumor necrosis factor alpha (TNF-), reactive oxygen species (ROS) and essentially activity to kill tumor cells and pathogens (60)