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To address this, scaffold-based splittingpartitioning compounds based on BemisMurcko scaffoldshas become a gold standard for small-molecule drug discovery, as it better simulates real-world scenarios in which a model encounters novel chemotypes 85,86
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doi: 10.1182/blood-2011-04-346825 41 CastriconiRDonderoABelloraFMorettaLCastellanoALocatelliFet al
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This is why CJC-1295 and Ipamorelin are often presented as a combination in research peptide discussions
