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Blood 103:19341936 Lekawanvijit S, Chattipakorn N (2009) Iron overload thalassemic cardiomyopathy: iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

Priapism (prolonged erection) In rare cases, trazodone can cause a painful, persistent erection

Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

Methionine plays a role in breaking down fats, helping to prevent the buildup of fatty deposits in blood vessels that might cause coronary artery disease and blockages in the neck and legs

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