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The observed analgesic effects are likely mediated by the modulation of glutamatergic systems, particularly involving both selective and non-selective opioid receptors

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Figure 1 Paracetamol for the Early Management of COVID-19: A Critical Viewpoint As discussed above, a precautionary principle regarding the risk of bacterial superinfections and of ACE2 overexpression was the main reason for the decision to discourage the use of NSAIDs (Micallef et al., 2020a

But trending does not mean new, and popular does not mean well understood