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In fact, HaCat cells stimulated by proinflammatory cytokines, IL17 and IL22, showed an increased Nrf2 accumulation and subsequent induction of keratin expression such as keratin 6, 16, and 17, contributing to hyperkeratinization that could be observed in psoriasis

When L-Glutamine is introduced to damaged enterocytes, it induces the transactivation of the Epidermal Growth Factor Receptor (EGFR)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Vachtenheim J., Borovansk J