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In an ADHD comorbid disease, major depressive disorder, activated astrocytes can reduce glutamate on the synaptic cleft via excitatory amino acid transporters (EAATs) and convert it to glutamine in the cytosol [162]

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This balanced inflammatory modulation prevents the chronic inflammation associated with impaired healing in diabetic or venous insufficiency ulcers, while avoiding excessive immunosuppression that could increase infection risks

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