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Furthermore, the authors showed that miR-143/145 inhibited CRC cell proliferation in vitro , by inhibiting IGF1R expression highlighting their tumor suppressor activity in CRC, the importance of IGF1R in CRC pathogenesis, and underlying a novel regulatory network to fine-tune cell proliferation (87)

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Plasma MOTS-c itself is not yet widely available as a clinical laboratory test, though research assays exist

Multiple investigations have revealed that combinations of environmental contaminants, such as heavy metals, pesticides, and airborne particulates, can produce additive or synergistic interactions that significantly intensify carcinogenic effects [259,260]

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