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Nassif explained

These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism

You might feel tired or groggy as a result

"How Nature builds the pigments of life" (PDF)

You can see how vitamin and mineral supplements might help people who are deficient, but might a supplement like vitamin B12 help people who are not vitamin B12 deficient
