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Wang C, Zhao M, Liu Y-R, Luan X, Guan Y-Y, Lu Q, et al

Inclisiran is a synthetic double-stranded siRNA that has been modified with phosphorothioate substitutions and with the addition of 2-deoxy, 2-fluoro-RNA, 2- O -methyl-RNA nucleotides which increase the stability and thus, the longevity and potency of the construct

SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

Before considering this combination, your provider should assess your baseline oxidative stress status, medication interactions, kidney and liver function, and whether evidence supports intervention