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3.6 Integrated transcriptomicproteomic analysis 3.6.1 Overview of differential expression at transcriptomic and proteomic levels Among 17,251 genes analyzed, 116 DEGs (0.67%) were identified, comprising 41 up-regulated and 75 down-regulated genes

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For peptides, threshold varies by endpoint

A significant dose-response relationship between ibuprofen intake (tablets/week) and reduced PD risk was found

These disparities substantially limit data integration and model generalizability across research centers