p21 and glutathione Role of in Cancer: From Mechanisms to Therapies or poly Inhibition of p21‐mediated ROS accumulation

Ramirez-Zamora, A

Am J Cancer Res 14(5):23262342 Li Y et al (2024b) Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery

The study on Sendai in 1997 showed that adsorption of Sendai virus to the cell wall caused a loss of GSH, which affected the Na + /H + antiporter leading to a lower intracellular pH

In a subsequent publication, Gaitan et al

Unlike most abundantly synthesized molecules, such as ATP or DNA, the production of GSH is controlled at the enzymatic level by a holoenzyme, glutamate-cysteine ligase (GCL), a heterodimer composed of a catalytic subunit (GCLC), and a modifier subunit (GCLM)