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In the exogenous pathway, the generation of ROS is driven by extracellular stimuli, including hypoxia, growth factors, inflammatory mediators, ionizing radiation, and heavy metals (12, 13)

In order to preserve tiny molecules from degradation or to facilitate the absorption and distribution of natural antioxidants, polymeric nanoparticles are used to encapsulate or integrate the molecules

Celastrol activates the major heat shock transcription factor Hsf-1, 19 and the protective effect of heat shock against aminoglycoside-induced hair cell death is dependent on Hsf-1

Using a liposomal format usually mitigates this issue because it is absorbed more efficiently

doi: 10.1371/journal.pbio.0050177 586 DecodeME