melanotic macules genital Male dermatology. Part 2: Noninflammatory lesions 2024.2.6.vulvar_pigmented - Our Dermatology Online

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Standard protocol uses 0.250.5mg daily for 57 days (loading phase), then 0.25mg 23 times weekly (maintenance phase) to sustain pigmentation depth

Dutta SW, Showalter SL, Showalter TN, Libby B, Trifiletti DM

This priming-dependent enhanced phosphorylation aligns with our in vivo post-translational modification analysis: S114 phosphorylation is consistently detectable, whereas downstream residues S117 and S120 remain elusive, likely due to the transient nature of their phosphorylation following S114 priming