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Impact of Changes in Free Concentrations and Drug-Protein Binding on Drug Dosing Regimens in Special Populations and Disease States

These pathways involve key enzymes including S-methyl-5-thioadenosine phosphorylase (MTAP), methylthioribose-1-phosphate isomerase (MRI1), cystathionine beta-synthase (CBS), and cystathionine gamma-lyase (CTH) (Fig

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10.1007/s12263-007-0055-0 15 BucioliS

[DOI] [PubMed] [Google Scholar] 41.Bloomer RJ, Falvo MJ, Schilling BK, Smith WA