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Due to the lack of approval from the US Food and Drug Administration, Cingal injections have yet to reach a wider market in the region
This suggests that LCS3 does not compete directly with the cellular substrates of these enzymes in their free state, but rather inhibits the enzymes following the formation of an enzyme-substrate complex (34)
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The models based on keratinocyte cell cultures also proved to be unsuitable for estimating the rate of transepidermal transport

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