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In contrast the findings for glutamine were inconsistent with two studies reporting no significant difference in serum glutamine in children with autistic disorder compared with controls [69, 89], a later study reporting a significant decrease in platelet glutamine in children with autistic disorder [68] and further studies that reported serum glutamate to be significantly higher in adults with autistic disorder [75] and children with autism spectrum disorders (mixed diagnoses) than controls [87]

Moreover, recruitment of this triple combination therapy regimen can reduce the incidence of inflammation and skin irritation induced by hydroquinone or retinoids (Gupta et al., 2006)

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