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In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients

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added a double bind, placebo-controlled RCT of 72 patients with a mean follow-up of 92 weeks (54 - 157 weeks) to the latters meta-analysis which yielded similar results

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Selective 5-HT6 receptor ligands progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders