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These multi-protein complexes include BCL9 and Pygopus (Pygo), Mediator (for transcription initiation), p300/CBP and TRRAP/TIP60 histone acetyltransferases (HATs), MLL1/2 histone methyltransferases (HMTs), the SWI/SNF family of ATPases for chromatin remodeling, and the PAF1 complex for transcription elongation and histone modifications (Mosimann et al., 2009

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Perimetry assessments typically unveil classic centrocaecal or central scotomas, accompanied by funduscopic examinations displaying nerve fiber layer swelling, vascular tortuosity, retinal hemorrhages, circumpapillary telangiectatic microangiopathy, and axonal loss within the papillomacular bundle region [475,482,483]