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Hansson, 2009)

You should also note that there are guidelines regarding how much coffee is safe to consume due to the high caffeine content

Oral citicoline (four cycles of 500 mg/day for four months followed by a two-month washout period) was also found to significantly reduce the rate of visual field loss and the level of intraocular pressure in 41 patients with progressive glaucoma (89)

Rocha MC, Grady JP, Grnewald A et al

Moreover, low serum concentrations of vitamin B 12 during pregnancy have been linked to an increased risk for NTDs (87), and there is concern that folic acid supplementation during pregnancy may mask the clinical diagnosis of vitamin B 12 deficiency