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A water molecule in the close vicinity of Gln390 hydrogen bonded to the hydroxyl group of Ser388 and -amino group of Gly484 has been reported to enhance nucleophilicity of OG atom of Thr391 that appears crucial in autoprocessing (Figure 2

doi: 10.1016/j.jmb.2017.01.017 4 ChenSLiaoZXuP

We find that both increasing age and microbial depletion sensitize Drosophila to acetaminophen toxicity

High-dose B6 supplementation, when done wrong, can lead to the unpleasant paradox of vitamin B6 toxicity, a growing population-wide problem of its own

Targeting fatty acid metabolism as anovel therapeutic strategy for hematological malignancies: The achilles heel of the warburg effect