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Although structurally similar to other ZNT family members that transport Zn, ZNT10 also functions as a Mn exporter (Nishito et al., 2016

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Genet 21 , 4462 (2020)

Figure 1 Ferroptosis, a recently identified form of programmed cell death, is characterized by elevated levels of reactive oxygen species (ROS) and iron-dependent lipid peroxidation ( + to Fe + occurs after cellular iron uptake through transferrin receptor 1 (TFR1)

Marro, S., et al., Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position 7007 of the FPN1 promoter