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Rivaroxaban, a direct factor Xa inhibitor, ameliorates hypertensive renal damage through inhibition of the inflammatory response mediated by protease-activated receptor pathway

Moreover, direct administration of cysteine to increase GSH is not a viable option, because of its poor absorption and toxicity at high doses (Johnson et al., 2012)

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Given the importance of glucose and glutamine metabolism in pancreatic cancer cells, it is not surprising that gemcitabine resistance is closely associated with metabolic status, including cellular glucose and glutamine levels