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Additionally, GM treatment markedly reduced renal superoxide dismutase (SOD) activity and depleted mitochondrial glutathione (GSH), nicotinamide adenine dinucleotide (NADH) dehydrogenase, Bcl-2, and cytochrome-c (Cyt-C) oxidase levels

Notable gray matter volume reductions have been detected in voxel-based morphometry studies, especially within the anterior cingulate cortex and prefrontal cortex [133]

It is reported that BBB functioning is affected even before the immune cells migrate to the site of inflammation [60]

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In contrast, antihypertensive treatment with hydralazine significantly lowered blood pressure but failed to normalize vascular superoxide formation, despite increasing sGC expression