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Also, free radicals can damage sperm DNA through oxidation of purine and pyrimidine bases, breakage of DNA single and double strands, protamine deficiency, chromosomal rearrangement and gene mutation and the detrimental consequences are cell damage, cell apoptosis, and impaired fetus development

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Severe liver steatosis has been frequently found in patients infected with the genotype 3a virus (Rubbia-Brandt et al., 2000

3135 TMAO has been confirmed by many studies to participate in the inflammatory response in the body and activates multiple proinflammatory signal pathways