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Flavin-containing monooxygenase 3 as a potential player in diabe-tes-associated atherosclerosis

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2017 meta-analysis: A systematic review and meta-analysis of nine randomized controlled trials showed that ALCAR supplementation significantly decreased depressive symptoms compared to placebo (standardized mean difference 1.10, 95% CI 1.65 to 0.56), with effects comparable to established antidepressants like fluoxetine, particularly in older adults or those with treatment-resistant depression [5][30]

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Wang Z., Tang W.H.W., Buffa J.A., Fu X., Britt E.B., Koeth R.A., Levison B.S., Fan Y., Wu Y., Hazen S.L