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SCFAs like butyrate, which are generated through probiotic fermentation of dietary fiber, inhibit HDACs, leading to epigenetic silencing of pro-inflammatory cytokines (e.g., IL-1, TNF-) by downregulating NF-B and upregulating IL-10 by activating STAT3 (98, 102, 103)

Just as we use a discount rate on future cash flows to figure out retirement, were doing the same thing on physiologic parameters

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B.et al (2014)

What happens if it gets warm Brief exposure to room temperature, like during a dose draw, is fine