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Stem cells: recent developments redefining epilepsy therapy

The tumor suppressor protein p53 increases the expression of the aspartate/glutamate transporter SLC1A3 and the arginine transporter SLC7A3 upon glutamine depletion, leading to resistance to treatments that deplete extracellular glutamine 114,115

These mechanisms work together to suppress tumor growth and prevent cancer progression

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Thus, it is reasonable to speculate that better neuronal function following CAR treatment may be associated with BBB protection and suppression of the ROS/NF-B/MMP-9 pathway