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Under physiological conditions, oxidative free radicals generated by the mitochondrial oxidative respiratory chain, endoplasmic reticulum, and NADPH oxidases can be effectively neutralized by NRF2-mediated antioxidant responses

International Journal of Cosmetic Science , 41(5), 465-474

An early symptomatic stage of the disease was selected to investigate whether metabolomic perturbations begin to occur early in the motor cortex with TDP-43 pathology
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