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Karuppagounder, S

Diminished efficacy of programmed death-(ligand)1 inhibition in STK11- and KEAP1-mutant lung adenocarcinoma is affected by KRAS mutation status

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[23] Symptoms are abdominal pain, a continuous feeling of a full bladder, frequent urination, acute urinary retention (inability to urinate), pain during urination (dysuria), problems starting urination (urinary hesitancy), slow urine flow, starting and stopping (urinary intermittency), and nocturia

Mice engineered to carry the Cys93Ala mutation, which eliminates the thiol group, are unable to generate SNO-Hb and show impaired regulation of blood flow during hypoxia (Sun et al., 2019)