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10.1002/mrm.25549
For lupus-related joint involvement, both peptides address different aspects of tissue damage and inflammation
Simultaneously, angiogenesis-related factors induce macrophage polarization toward the M2 phenotype, thereby leading to the development of an immunosuppressive tumor microenvironment (TME)

Because tumors possess an inflammatory microenvironment, a standing question in the field pertains to the role of inflammation in modulating the proteasomes composition and activity, and consequently, how it shapes peptide presentation and the immunopeptidome
