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Oral morphine is poorly absorbed by oral administration, but it is probably due more to its water (aqueous) solubility than a first-pass effect

And the research supporting this delivery method, while promising, comes with important caveats that every informed researcher should understand before making the switch

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In general, the symptoms of vitamin toxicity include nausea, gastrointestinal problems like constipation and diarrhea, hair loss, rashes, and nerve damage