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The reaction is catalysed by uridine diphosphate glucuronosyltransferase (UGT) which is mainly present in liver and adjacent to CYP-450 in the endoplasmic reticulum (ER) of the liver

d , Oxygen consumption rate (OCR) determined by Seahorse analysis in HepG2 cells treated with or without NaOX overnight

Chronic injuries that have been present for months or years generally take longer

Small-molecule inhibitors of copper chaperone proteins The clinical use of copper ion chelators often leads to low copper ion concentrations, resulting in serious toxic side effects that disrupt other normal physiologic processes that require copper ions