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The manifestations of mitochondrial dysfunction are complex and diverse in SIC, mainly in the electron transport chain and oxidative phosphorylation abnormalities, mitochondrial structure abnormalities, oxidative and nitrite stress, mitochondrial calcium overload, mitochondrial autophagy dysregulation, and mitochondrial dynamics imbalance (3537)

The human body is adapted to survive these periods with no or limited food availability by adapting its substrate preference to sustain bodily functions

10.1210/jc.2003-031291 148 VellosoC

Certain medications for blood pressure, thyroid conditions, or arrhythmias interact with GLP-1 receptor agonists in ways that affect cardiac rate and rhythm

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