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2,100 For instance, elevated levels of copper in the tumor tissue and serum have been observed in patients with oral, 101 thyroid, 102 breast, 103,104 lung, 105,106 pancreatic, 107 gallbladder, 108 colorectal, 109 prostate, 110 and gynecological cancers, 111 and are significantly associated with poor prognostic outcomes
Studies in rats suggested that PI3K mediates pain behavior by activating the peripheral EphrinBs/EphBs signaling pathway 47 while AKT is involved in phosphorylation of Thr308 and Ser473 to regulate diverse biological processes 48
SLC7A11 is highly expressed in human tumors, and its overexpression inhibited ROS-induced ferroptosis and abrogates p53-mediated tumor growth suppression in xenograft models [61]
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PLoS ONE 8 , e72533 (2013)
