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Lu R, Zhang X, Li X, Wan X

10.1097/COC.0b013e318246b50d 4 Alessandri-HaberN.DinaO

This not only exacerbates oxidative stress but also impairs antioxidant defense capacity.48,52 Additionally, a study has found that magnesium deficiency causes excessive ROS production and low-grade inflammation, which in turn accelerates the depletion of telomeres and affects sleep.53 Meanwhile, Magnesium is indispensable for the normal functioning of -glutamyl transpeptidase, an enzyme that fulfills a critical role in the synthesis of the antioxidant glutathione.54 It has also been confirmed that magnesium possesses a mild antioxidant effect.55 Current research has further confirmed that low dietary magnesium intake is associated with elevated plasma C-reactive protein (CRP) levels.50,56 CRP serves as a marker of inflammatory stress, and one possible factor contributing to increased inflammatory stress is sleep disruption or sleep deprivation.57 Inadequate sleep duration has been linked to elevated levels of various inflammatory biomarkers, including plasma CRP

Peffer, R

Although this isoform is not directly related to drug metabolism, it is associated with liver dysfunction due to the accumulation of bile acids, which could disrupt enterohepatic recirculation and, therefore, indirectly affect drug metabolism (Zhang et al., 2015)