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In placebo group, 4.26% of patients experienced adverse events, including pyrosis, intense thirst and cholestasis, none of which was manifested as clinically relevant

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Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS
Experimental Physiology 2008;93:1139-1146

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