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Patients suffering from temporal lobe epilepsy, with sclerotic astrocytes and neuronal loss, often display a combination of highly elevated extracellular glutamate concentrations, also interictally, interictal hypometabolism, reduced glutamine synthetase activity and greatly reduced glutamine formation from glutamate (Petroff et al., 2002a,b

You deal with inflammation or swelling that doesnt go away

Annals of surgical oncology 33(6):5348-5357, 2026

Once reconstituted, that stability window narrows significantly, which is why technique and storage are so important in research environments

doi: 10.1080/02640410903473844 [DOI] [PubMed] [Google Scholar] [61].Nieman DC, Shanely RA, Luo B, et al